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As shown by national reports on anaemia in Iran, the prevalence of iron deficiency among 15 to 49-years-old-females is 39% ( Salehian and UNICEF, 1995). Over 90% of affected individuals live in developing countries ( ACC/SCN, 1997). More than 2 billion people, mainly young women and children, are iron-deficient ( WHO/UNICEF/UNN, 1998). It is a major public health problem with adverse consequences, especially for women and children. Iron deficiency anaemia is the most prevalent nutritional deficiency worldwide.
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This study was supported by the Dean of Research Affairs of the Tehran University of Medical Sciences. Our results indicate that improvement of iron status was accompanied by an improvement in some indices of thyroid hormones. These two groups did not differ for any of the four indices, but both differed significantly from the iodine and placebo groups. Thyroid indices tT4, tT3 and T3RU increased and reverse RT3 decreased in the iron+iodine group (10 vs 8.9 μg/dl, P< 0.001 143 vs 138 μg/dl, P<0.05 32.3 vs 28.4%, P<0.001 and 24.8 vs 44.2 ng/dl, P<0.001, respectively) and in the iron group. Urinary iodine doubled in the iron+iodine group and in the iodine group ( P<0.001 for both). After the intervention, there was a significant increase in ferritin and transferrin saturation in the iron+iodine group (17.6 vs 8.7 μg/dl, and 18.8 vs 7.2%, respectively, P<0.001 for both) and in the iron group ( P<0.001 for both). Results:Īll groups were comparable at baseline.
#SPSS 25 CONCURRENT ADMINISTRATORS PLUS#
Patients were randomly assigned to one of four groups and treated with a single oral dose of 190 mg iodine plus 300 mg ferrous sulphate 5 times/week ( n=24), 300 mg ferrous sulphate 5 times/week ( n=23), a single oral dose of 190 mg iodine ( n=25), or a placebo ( n=22) for 12 weeks. Subjects:ġ03 iron-deficient non-anaemic girls who fulfilled all inclusion criteria were included, and 94 subjects successfully completed the study. The study was performed from 2002 through 2003 in the Islamic Republic of Iran. Design:Ī double-blind randomized intervention study. These results suggested that adult-onset hypothyroidism induce morphological, biochemical and molecular alterations in the PFC, combined administration of T4 and DON induce plastic changes in the PFC, different from that of the standard T4 therapy, and that the DON treatment may facilitate the recovery of synaptic protein impairments induced by hypothyroidism.To investigate whether iron supplementation can improve thyroid hormone function in iron-deficient adolescent girls. At the protein level, hypothyroidism increased the levels of syt-1 and SNAP-25 in the PFC, both of which were not restored to control values following T4 administration, while concurrent administration of T4 and DON was able to induce this effect. In addition, DON treatment restored ACh content to normal. Moreover, hypothyroidism significantly decreased the content of ACh (29.8%) and activity of AChE (27.8%), which were restored to control values by T4 administration. T4 or DON treatment improved the morphologic features of the PFC, and the performance of the T4 combined DON group was the closest to the control group. Transmission electron microscope analysis revealed that hypothyroidism induced marked ultrastructural changes, including the neurons, the synapses and the myelin sheath in the PFC. The animals were treated with T4 and DON administered separately or in combination from the fifth week. Adding 0.05% propylthiouracil to rats' drinking water induced a hypothyroid rat model. The acetylcholine (ACh) content and AChE activity was assessed, as well as the expressions of synaptotagmin-1 (syt-1) and SNAP-25 were analyzed in the rats. Abstract : The aim of the present study was to observe the effects of the concurrent administration of thyroxine (T4) and an acetylcholinesterase (AChE) inhibitor, donepezil (DON), on the hypothyroidism-induced ultrastructural changes of the prefrontal cortex (PFC) in adult rats.